Does multiple sclerosis affect glucose tolerance?

作者：Wens I^*; Dalgas U; Deckx N; Cools N; Eijnde B O

来源：Multiple Sclerosis, 2014, 20(9): 1273-1276.

DOI：10.1177/1352458513515957

• Impaired glucose tolerance
• multiple sclerosis
• insulin
• diabetes type II

Based on current literature, it is not clear if multiple sclerosis (MS) patients are at increased risk to develop impaired glucose tolerance (IGT). Eighty-one MS patients and 45 healthy controls (HC) performed an oral glucose tolerance test. IGT was defined as a fasting glucose concentration of 6.1-6.9 mmol/l and two-hour post-load glucose of 7.8-11.1 mmol/l. The prevalence of impaired fasting glucose concentrations (17% vs 2%) and IGT (11% vs 0%) was higher in MS patients than HC. Accordingly, the areas under the glucose and insulin curves were higher in MS patients. The current study demonstrates an elevated IGT-prevalence in MS.

• 出版日期2014-8