Association of Leukocyte Telomere Length and Mitochondrial DNA Copy Number in Children from Salamanca, Mexico

作者：Alejandro Alegria Torres Jorge; Velazquez Villafana Marion; Manuel Lopez Gutierrez Juan; Chagoyan Martinez Marcela M; Rocha Amador Diana O; Costilla Salazar Rogelio; Garcia Torres Lizeth

来源：Genetic Testing and Molecular Biomarkers, 2016, 20(11): 654-659.

DOI：10.1089/gtmb.2016.0176

• Mexican children
• telomere length
• mitochondrial DNA copy number

Aim: The purpose of this study was to determine if there is a correlation between telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) in children. Methods: Leukocyte TL and mtDNAcn were measured by real-time PCR in 98 Mexican children 6-12 years of age from Salamanca, Mexico. Results: A positive association was found between TL and mtDNAcn after a natural log transformation (Pearson correlation r = 0.72; p < 0.0001). No correlation between age and body mass index (BMI) biomarkers was found, and no differences according to sex were observed. After adjustment for these variables, a linear regression model showed an association between TL and mtDNAcn (beta = 0.739, 95% confidence interval 0.594; 0.885, p < 0.0001). Conclusions: A strong positive correlation between TL and mtDNAcn was found in the study population; age, sex, and BMI seemed to have no effect on this correlation.

• 出版日期2016-11