Alphavirus replicon particle vaccines developed for use in humans induce high levels of antibodies to influenza virus hemagglutinin in swine: Proof of concept

作者：Erdman M M; Kamrud K I; Harris D L^*; Smith J

来源：Vaccine, 2010, 28(3): 594-596.

DOI：10.1016/j.vaccine.2009.10.015

• Alphavirus
• Influenza
• Virus
• Swine
• Human
• Hemagglutinin
• Antibodies
• VEEV
• Replicon particle

A propagation-defective, single-cycle, alphavirus replicon particle (RP) system was used to produce two vaccines against human influenza virus A/Wyoming/0312003 (H3N2). One vaccine was prepared from Venezeulan equine encephalitis virus (VEEV) strain 3014 and the other from VEEV strain TC-83. Both vaccines induced high antibody titers to the influenza hemagglutinin (HA) protein and illustrated the potential of using alphavirus RP influenza vaccines in swine.

• 出版日期2010-1-8