Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice

作者：Choi Yunsik; Lee Sanghyuk; Kim Kapyoul; Kim Soo Hyun; Chung Yeun Jun^*; Lee Charles^*

来源：Experimental and Molecular Medicine, 2018, 50(8): 99.

DOI：10.1038/s12276-018-0115-0

Cancer immunotherapy is a promising way to eliminate tumor cells by using the patient's own immune system. Selecting the appropriate animal models to develop or validate preclinical immunotherapeutic trials is now an important aspect of many cancer research programs. Here we discuss the advantages and limitations of using genetically engineered immunodeficient mouse models, patient-derived xenografts (PDXs), and humanized mouse models for developing and testing immunotherapeutic strategies.

• 出版日期2018-8-7