Protective effect of ferulic acid and resveratrol against alloxan-induced diabetes in mice

作者：Ramar Manikandan^*; Manikandan Beulaja; Raman Thiagarajan; Priyadarsini Asokan; Palanisamy Subramanian; Velayudam Meiyalagan; Munusamy Arumugam; Prabhu Narayanan Marimuthu; Vaseeharan Baskaralingam

来源：European Journal of Pharmacology, 2012, 690(1-3): 226-235.

DOI：10.1016/j.ejphar.2012.05.019

• Diabetes
• Alloxan
• Ferulic acid
• Resveratrol
• Nuclear factor-kappa B

The present study was to investigate the effect of ferulic acid and resveratrol on alloxan-induced diabetic mice, through analysis of basic biochemical parameters, enzymic as well as non-enzymic activities, lipid peroxidation and immunohistochemical studies. Alloxan was administered as a single dose (75mg/kg body weight) to induce diabetes in mice. A dose of ferulic acid (10mg/kg body weight) and resveratrol (20mg/kg body weight) were administrated orally and intraperitoneally, respectively, to the alloxan-induced diabetic mice. The levels of basic biochemical markers and lipid peroxidase were significantly (P < 0.05) increased in alloxan-induced diabetic mice. The levels of antioxidants were significantly (P < 0.05) decreased in liver, kidney and serum. Immunohistochemical studies in alloxan induced mice demonstrated a marked increase in the immunoreactivity of nuclear transcription factor (NF-kappa B). Treating the diabetic mice with doses of ferulic acid and resveratrol restored the changes in the above parameters analysed. The present study, showed that ferulic acid and resveratrol exerted antioxidant as well as anti-diabetic effects, consequently alleviate liver and kidney damage caused by alloxan-induced diabetes, probably through inhibition of the proinflammatory factor, NF-kappa B.

• 出版日期2012-9-5