A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis

作者：Wang Danher; Suhrbier Andreas; Penn Nicholson Adam; Woraratanadharm Jan; Gardner Joy; Luo Min; Le Thuy T; Anraku Itaru; Sakalian Michael; Einfeld David; Dong John Y^*

来源：Vaccine, 2011, 29(15): 2803-2809.

DOI：10.1016/j.vaccine.2011.01.108

• Chikungunya
• Adenovirus
• Vaccine
• Arthritis

Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. A single immunisation with this vaccine consistently induced high titres of anti-chikungunya virus antibodies that neutralised both an old Asian isolate and a Reunion Island isolate from the recent epidemic. The vaccine also completely protected mice against viraemia and arthritic disease caused by both virus isolates.

• 出版日期2011-3-24
• 单位河北医科大学