Autophagy in light-induced retinal damage

作者：Chen Yu; Perusek Lindsay; Maeda Akiko^*

来源：Experimental Eye Research, 2016, 144: 64-72.

DOI：10.1016/j.exer.2015.08.021

• Light-induced retinal damage
• Beclin1
• ATG7
• Park2
• All-trans-retinal
• Visual cycle

Vision is reliant upon converting photon signals to electrical information which is interpreted by the brain and therefore allowing us to receive information about our surroundings. However, when exposed to excessive light, photoreceptors and other types of cells in the retina can undergo light-induced cell death, termed light-induced retinal damage. In this review, we summarize our current knowledge regarding molecular events in the retina after excessive light exposure and mechanisms of light-induced retinal damage. We also introduce works which investigate potential roles of autophagy, an essential cellular mechanism required for maintaining homeostasis under stress conditions, in the illuminated retina and animal models of light-induced retinal damage.

• 出版日期2016-3
• 单位上海中医药大学