Association of Lp-PLA2 mass and heart failure in a cohort of Nantong population

作者：Sheng, Guohua; Shen, Yi; Wu, Xiang; Zhu, Jianhua; Qin, Xiaotong^*; Gui, Le^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(10): 14605-14613.

• Lipoprotein-associated phospholipase A2 mass
• heart failure
• epidemiology

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a useful inflammatory marker which correlated with the development of coronary artery disease (CAD). Inflammatory cytokines may be involved in the pathogenesis of ventricular dysfunction which contributes to the severity of heart failure (HF). However, the role of Lp-PLA2 in HF was not clear. We evaluated the association of Lp-PLA2 mass levels with the severity of HF with or without CAD and assessed this enzyme involved in these pathophysiologic processes in relation to left ventricular ejection fraction. Plasma Lp-PLA2 mass were measured in 652 HF patients with or without CAD and evaluated along with known risk indicators. Lp-PLA2 mass dramatically increased in advanced HF compared to mild/moderate HF (P<0.05). A negative correlation was found between Lp-PLA2 mass and left ventricular ejection fraction (LVEF) level in HF (r=-0.287, P<0.0001) and in HF without CAD (r=-0.306, P<0.0001). Lp-PLA2 mass was significantly associated with advanced HF after adjusted with age, gender, hypertension, diastolic blood pressure, statins, inclusion diagnosis of CAD and atrial fibrillation (95% CI=1.01-1.02, P<0.05). In conclusion, Lp-PLA2 mass was strongly and independently associated with advanced HF in this community-based cohort of patients.

• 出版日期2017
• 单位南通大学