Will SNPs be useful predictors of normal tissue radiosensitivity in the future?

作者：Andreassen Christian Nicolaj^*; Dikomey Ekkehard; Parliament Matthew; West Catharine Mary Louise

来源：Radiotherapy and Oncology, 2012, 105(3): 283-288.

DOI：10.1016/j.radonc.2012.11.003

• Normal tissue radiosensitivity
• Genetics
• Single nucleotide polymorphisms

The ability to predict individual risk of radiation-induced normal tissue complications is a long sought goal in radiobiology. The last decade saw increasing interest in identifying associations between single nucleotide polymorphisms (SNPs) and normal tissue complication risk. Nevertheless, it remains controversial whether SNPs will be useful predictors of normal tissue radiosensitivity. This paper provides a summary of a scientific debate held at the 31st ESTRO conference in which four scientists argued in favor or against the motion that SNPs will be useful predictors of normal tissue radiosensitivity in the future.

• 出版日期2012-12