An Efficient and Direct Synthesis of 2-Thiopyridines via Microwave-Assisted Three-Component Reaction

作者:Wang Xing Han; Cao Xu Dong; Tu Shu Jiang*; Zhang Xiao Hong; Hao Wen Juan; Yan Shu; Wu Shan Shan; Han Zheng Guo; Shi Feng
来源:Journal of Heterocyclic Chemistry, 2009, 46(5): 886-889.
DOI:10.1002/jhet.161

摘要

A series of 2-p-tolylthiopyridine derivatives was directly synthesized via three-component reactions of chalcones, malononitrile, and 4-methylbenzenethiol catalyzed by Et(3)N in DMF under microwave irradiation. It is an efficient and promising synthetic strategy to construct 2-thiopyridine skeleton with the advantage of short time, excellent yield, and convenient operation.