Anthraquinone Profile, Antioxidant and Antimicrobial Properties of Bark Extracts of Rhamnus catharticus and R. orbiculatus

作者：Locatelli Marcello; Epifano Francesco; Genovese Salvatore; Carlucci Giuseppe; Koncic Marijana Zovko; Kosalec Ivan; Kremer Dario^*

来源：Natural Product Communications, 2011, 6(9): 1275-1280.

• Rhamnus catharticus
• Rhamnus orbiculatus
• anthraquinone profile
• antioxidant activity
• antimicrobial activity

The anthraquinone profile, antioxidant and antimicrobial activities as well as the total phenol and total flavonoid contents were determined in methanol extracts of the barks of Rhamnus catharticus L. and R. orbiculatus Bornm. The most abundant anthraquinone derivatives in R. catharticus were physcion (67.8%) and emodin (26.2%), while R. orbiculatus contained mostly physcion (81.3%) and chrysophanol (14.6%). R. catharticus displayed better activity in the beta-carotene-linoleic acid assay, as well as chelating activity, whereas its activity in the reducing power assay was significantly lower than that of R. orbiculatus. Both methanol extracts showed antimicrobial activity against all microbial species tested (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia colt, Candida albicans, Aspergillus niger, Microsporum gypseum) with MIC values either equal to or lower than 2.50 mg/mL. R. catharticus and R. orbiculatus contained several anthranoid aglycones and their bark extracts demonstrated notable antioxidant and antimicrobial properties. The results obtained indicate the medicinal potential of these two species.

• 出版日期2011-9