Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers: A Promising Medication for Chronic Obstructive Pulmonary Disease?

作者：Vasileiadis Ioannis E^*; Goudis Christos A; Giannakopoulou Pinelopi T; Liu Tong

来源：Journal of Chronic Obstructive Pulmonary Disease, 2018, 15(2): 148-156.

DOI：10.1080/15412555.2018.1432034

• Angiotensin converting enzyme inhibitor
• angiotensin receptor blocker
• chronic obstructive pulmonary disease
• renin-angiotensin system

Chronic obstructive pulmonary disease (COPD) is a complex disorder that primarily affects the lungs and is characterized not only by local pulmonary, but also by systemic inflammation which promotes the development of extrapulmonary and cardiovascular co-morbidities. Angiotensin converting enzyme (ACE) inhibitors and ARBs (angiotensin receptor blockers) are widely used drugs in the treatment of cardiovascular diseases, with growing evidence suggesting potential benefits in COPD patients. The purpose of this review is to describe the correlation of renin-angiotensin system(RAS) with COPD pathophysiology and to present the latest data regarding the potential role of RAS blockers in COPD.

• 出版日期2018
• 单位天津医科大学