A Domino Diels-Alder Approach toward the Tetracyclic Nicandrenone Framework

作者：Mackay Emily G; Noerret Marck; Wong Leon S M; Louis Ignace; Lawrence Andrew L; Willis Anthony C; Sherburn Michael S^*

来源：Organic Letters, 2015, 17(22): 5517-5519.

DOI：10.1021/acs.orglett.5b02412

The tetracarbocyclic framework of the nicandrenone natural products is formed in one step from a linear precursor via a domino intramolecular Diels-Alder/intramolecular furan Diels-Alder/aromatization sequence. The approach represents a new 0 -> ABCD strategy for the preparation of aromatic steroids.

• 出版日期2015-11-20