Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation

作者:Sadler Scott A; Hones Andrew C; Roberts Bryan; Blakemore David; Marder Todd B; Steel Patrick G*
来源:Journal of Organic Chemistry, 2015, 80(10): 5308-5314.
DOI:10.1021/acs.joc.5b00452

摘要

In the absence of a steric directing group, iridium-catalyzed. C-H borylation of N-protected indazoles occurs rapidly and selectively at C-3 and the resulting boronate esters can be utilized in a range of downstream conversions. The functional group tolerance of the iridium-catalyzed C-H borylation reaction enables simple and efficient multidirectional syntheses of substituted indazoles to be realized.

  • 出版日期2015-5-15