Direct Poly(beta-alanine) Synthesis via Polycondensation in Ionic Liquids

作者：Zhang Shaodong; Goncalves Leslie Dias; Lefebvre Herve; Tessier Martine; Rousseau Brigitte; Fradet Alain^*

来源：ACS Macro Letters, 2012, 1(8): 1079-1082.

DOI：10.1021/mz300264v

Poly(beta-alanine) was successfully synthesized by an alternative method, which is the direct polyamidation of beta-alanine in ionic liquids with triphenylphosphite as a condensing agent It was found that 1,3-dimethylimidazolium dimethylphosphate was the most suitable reaction medium, in which a number-average degree of polymerization up to 49.5 was obtained. It was shown that the method is also applicable to the direct synthesis of polypeptides, for example, poly(L-valine) and poly(L-isoleucine).

• 出版日期2012-8