Men with Hypertension are More Likely to Have Severe Lower Urinary Tract Symptoms and Large Prostate Volume

作者：Hwang Eu Chang; Kim Sun Ouck^*; Nam Deok Hyun; Yu Ho Song; Hwang Insang; Jung Seung Il; Kang Taek Won; Kwon Dong Deuk; Kim Geun Soo

来源：Lower Urinary Tract Symptoms, 2015, 7(1): 32-36.

DOI：10.1111/luts.12046

• hypertension
• lower urinary tract symptoms
• prostatic hyperplasia

ObjectivePatients with lower urinary tract symptoms (LUTS) have a higher prevalence of cardiovascular disease. We evaluated the correlation between LUTS and cardiovascular risk factors in men presenting with benign prostatic hyperplasia (BPH).
MethodsWe retrospectively reviewed the medical records of 295 men with transurethral resection of the prostate for the treatment of BPH and LUTS. Risk factors for cardiovascular disease included: hypertension, diabetes mellitus (DM), smoking, and dyslipidemia. The severity of LUTS measured by the International Prostatic Symptom Score (IPSS), prostate volume, prostate specific antigen (PSA), maximal urinary flow rate (Qmax), and postvoid residual urine (PVR) in subjects with or without cardiovascular risk factors were compared.
ResultsIPSS-total (22.97.8 vs. 21.2 +/- 7.3, P = 0.01) and obstructive symptom score (13.3 +/- 5.2 vs. 11.9 +/- 4.7, P = 0.01) was significantly different between men with hypertension and without cardiovascular risk factors. There was no significant difference of variables between subjects with DM, smoking or dyslipidemia and without cardiovascular risk factors. In the Pearson correlation, the systolic and diastolic blood pressure (BP) were related with prostate volume (r=0.138, P = 0.040; r=0.163, P = 0.020), IPSS-total (r=0.139, P = 0.043; r=0.138, P = 0.043), and an obstructive symptom score (r=0.168, P = 0.014; r=0.143, P = 0.037), respectively.
ConclusionsMen with hypertension are more likely to have a higher IPSS and large prostate volume than men without hypertension. This finding implicates a pathophysiological association between hypertension and LUTS, and the need to manage comorbid symptoms simultaneously.

• 出版日期2015-1