Well-being and immune response: a multi-system perspective

作者：Lasselin Julie; Alvarez Salas Elena; Grigoleit Jan Sebastian

来源：Current Opinion in Pharmacology, 2016, 29: 34-41.

DOI：10.1016/j.coph.2016.05.003

Whereas it is well-established that inflammation and other immune responses can change how we feel, most people are still surprised to hear that, conversely, well-being and its violations also affect our immune system. Here we show that those effects are highly adaptive and bear potential for both research and therapeutic applications. The studies discussed in this review demonstrate that immunity is tuned by ones emotions, personality, and social status as well as by other life style variables like sleep, nutrition, obesity, or exercise. We further provide a short excursion on the effects of stress and depression on immunity and discuss acute experimental endotoxemia as a model to study the effects of well-being on the innate immune response in humans.

• 出版日期2016-8
• 单位河北医科大学