Acetyl-cholinesterase Enzyme Inhibitory Effect of Calophyllum species

作者：Ee Gwendoline Cheng Lian^*; Teh Soek Sin; Mah Siau Hui; Jamaluddin Nur Ain; Sahimi Muhamad Syarik bin Muhamad; Ahmad Zuraini

来源：Tropical Journal of Pharmaceutical Research, 2015, 14(11): 2005-2008.

DOI：10.4314/tjpr.v14i11.8

• Calophyllum species
• Acetylcholinesterase
• Inhibitors

Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species.
Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (AChE) enzyme using Ellman's method.
Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of 100 mu g/mL, with the methanol extract of C. inophyllum demonstrating the strongest inhibitory effect of 81.28 % followed by the methanol extract of C. benjaminum with 74.32 % inhibition. The methanol extracts of Calophyllum inophyllum and Calophyllum bejaminum also showed significant inhibitory activity towards the acetylcholinesterase (AChE) enzyme.
Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development for acetyl-cholinesterase enzyme inhibition drugs.

• 出版日期2015-11