Size and surface effects on the MRI relaxivity of manganese ferrite nanoparticle contrast agents

作者：Tromsdorf Ulrich I; Bigall Nadja C; Kaul Michael G; Bruns Oliver T; Nikolic Marija S; Mollwitz Birgit; Sperling Ralph A; Reimer Rudolph; Hohenberg Heinz; Parak Wolfgang J; Forster Stephan; Beisiegel Ulrike; Adam Gerhard; Weller Horst^*

来源：Nano Letters, 2007, 7(8): 2422-2427.

DOI：10.1021/nl071099b

Superparamagnetic MnFe2O4 nanocrystals of different sizes were synthesized in high-boiling ether solvent and transferred into water using three different approaches. First, we applied a ligand exchange in order to form a water soluble polymer shell. Second, the particles were embedded into an amphiphilic polymer shell. Third, the nanoparticles were embedded into large micelles formed by lipids. Although all approaches lead to effective negative contrast enhancement, we observed significant differences concerning the magnitude of this effect. The transverse relaxivity, in particular r(2)*, is greatly higher for the micellar system compared to the polymer-coated particles using same-sized nanoparticles. We also observed an increase in transverse relaxivities with increasing particle size for the polymer-coated nanocrystals. The results are qualitatively compared with theoretical models describing the dependence of relaxivity on the size of magnetic spheres.

• 出版日期2007-8