Nanoemulsion is an effective antimicrobial for methicillin-resistant Staphylococcus aureus in infected wounds

作者：Cao Zhengyi; Spilker Theodore; Fan Yongyi; Kalikin Linda M; Ciotti Susan; LiPuma John J; Makidon Paul E; Wilkinson John Erby; Baker James R Jr^*; Wang Su He^*

来源：Nanomedicine, 2017, 12(10): 1177-1185.

DOI：10.2217/nnm-2017-0025

• antimicrobial
• infected wounds
• methicillin-resistant Staphylococcus aureus
• nanoemulsion
• NB-201

Aim: To develop NB-201, a nanoemulsion compound, as a novel microbicidal agent against methicillin-resistant Staphylococcus aureus (MRSA) infection, which is a common threat to public health but with limited therapeutic options. Materials & methods: NB-201 was tested in in vitro and in vivo murine and porcine models infected with MRSA. Results: Topical treatment of MRSA-infected wounds with NB-201 significantly decreased bacterial load and had no toxic effects on healthy skin tissues. NB-201 attenuated neutrophil sequestration in MRSA-infected wounds and inhibited epidermal and deep dermal inflammation. The levels of proinflammatory cytokines were reduced in NB-201-treated MRSA-infected wounds. Conclusion: NB-201 can greatly reduce inflammation characteristic of infected wounds and has antimicrobial activity that effectively kills MRSA regardless of the genetic basis of antibiotic resistance.

• 出版日期2017-5
• 单位河北医科大学