Near-infrared mediated chemo/photodynamic synergistic therapy with DOX-UCNPs@mSiO(2)/TiO2-TC nanocomposite

作者：Tong, Ruihan; Lin, Huiming^*; Chen, Yuhua; An, Na; Wang, Gang; Pan, Xiaofan; Qu, Fengyu^*

来源：Materials Science & Engineering C-Materials for Biological Applications, 2017, 78: 998-1005.

DOI：10.1016/j.msec.2017.04.112

• PDT
• Chemotherapy
• UCNPs@mSiO(2)
• NIR
• TiO2

To integrate photodynamic therapy (PDT) with chemotherapy for enhanced anticancer efficiency, near infrared (NIR) light mediated upconversion nanoparticles@mesoporous silica (UCNPs@mSiO(2)) nanovehicle was constructed as the nanocarrier. Based on the novel ultraviolet (UV) emission, TiO2 (3.0-3.2 eV) was adopted as the photosensitiver (PS) on account of the high activity and excellent stability. Here, a simple host-assembly method was exploited to graft it onto the inner and outer surface of the mSiO(2) shell. On the other hand, a UV cleavable o-nitrobenzyl derivative linker (TC linker) was prepared as "gate" to encapsulate anticancer agent doxorubicin (DOX) inside mSiO(2), insuring the few prematurity. Under NIR irradiation, the UV emission can excite TiO2 to produce reactive oxygen species (ROS) and also can induce the photodegradation of TC linker and drug release as well. The detailed release kinetics was studied to reveal that it is TC linker to manipulate the NIR-sensitive drug release and the amount of TC linker also can be used to adjust the release performance. The synergistic action of PDT and chemotherapy displays the improved cytotoxicity of DOX-UCNPs@mSiO(2)/TiO2-TC to HeLa cells under NIR irradiation that makes the potential application in anticancer field due to the superior to any single means.

• 出版日期2017-9-1
• 单位哈尔滨师范大学