Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

作者：Dillon Patrick M^*; Chakraborty Samhita; Moskaluk Christopher A; Joshi Prashant J; Thomas Christopher Y

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2016, 38(4): 620-627.

DOI：10.1002/hed.23925

• adenoid cystic carcinoma
• salivary gland
• tyrosine kinase inhibitor
• MYB gene
• NFIB gene
• nuclear factor I/B

Background. Adenoid cystic carcinoma (ACC) is a rare tumor of secretory glands. In this study, recent advances in molecular characterization and in therapeutics are reviewed.
Methods. A search of articles in PubMed and of abstracts from national meetings was performed regarding ACC.
Results. Recent genetic analyses found that recurrent chromosome 6: 9 translocations in ACC generate an MYB:NFIB gene fusion resulting in overexpression of the MYB oncoprotein. Several other frequent mutations are recently published that may be relevant for drug development. Several trials of targeted drugs are reviewed. Some agents delay tumor progression, but tumor responses remain rare.
Conclusion. ACCs have a characteristic chromosomal translocation, but also frequently pick up additional mutations. Clinical research is limited by the rarity and slow growth of ACC. Several ongoing trials are testing agents that inhibit fibroblast growth factor receptor signaling or other signaling pathways. Novel treatments based on the recently sequenced tumor genome are under development.

• 出版日期2016-4