DETERMINATION OF PARACETAMOL USING A FLOW INJECTION ANALYSIS WITH MULTICOMMUTATION AND CHEMILUMINESCENCE DETECTION.

作者：Oliveira Geiser G^*; Janegitz Bruno C; Batistao Marina B; Salami Fernanda H; Fatibello Filho Orlando; Leite Oldair D

来源：Quimica Nova, 2009, 32(7): 1755-1759.

• paracetamol
• chemiluminescence
• flow injection analysis

DETERMINATION OF PARACETAMOL USING A FLOW INJECTION ANALYSIS WITH MULTICOMMUTATION AND CHEMILUMINESCENCE DETECTION. A flow injection chemiluminescence method for the determination of paracetamol in pharmaceutical formulations is described. It is based on the consumption of the sodium hypochlorite by paracetamol and decreases of the analytical signal. The analytical curve was linear in the paracetamol concentration range from 5.0 x 10(-6) to 5.0 x 10(-5) mol L(-1), with a detection limit of 1.8 x 10(-6) mol L(-1). The RSDs were 2.0 and 1.2% respectively for 2.0 x 10(-5) and 4.0 x 10(-5) mol L(-1) paracetamol solutions (n = 10) and a sampling frequency of 180 h(-1) was obtained.

• 出版日期2009