Multicomponent Reactions Stereo- and Regioselective Three-Component Reaction in Water: Synthesis of Triazole Substituted beta-Lactams Via Click Chemistry

作者：Lei Ming^*; Song Wang Ze; Zhan Zu Jin; Cui Sun Liang; Zhong Fang Rui

来源：Letters in Organic Chemistry, 2011, 8(3): 163-169.

• Three-component reaction
• beta-lactam
• (3R,4R)-4-acetoxy-3-[(R)-1-((tert-butyldimethyl-silyl)oxy)-ethyl]-2-azet idinone
• click reaction
• triazole
• stereo-and regioselective reaction

Three-component reaction in water was used to prepare a series of triazole substituted trans-beta-lactams from the corresponding trans-4-acetoxy-lactam, sodium azide, and alkynes via a Cu(I)-catalyzed click chemistry with base free. This highly stereo-and regioselective procedure is simple, clean and efficient.

• 出版日期2011-3
• 单位浙江大学