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摘要
Background and aims This study evaluated the factors associated with bone mineral density (BMD) in chronic peritoneal dialysis (CPD) patients Methods In this cross-sectional study in 91 stable CPD patients, BMD was measured using dual-energy X-ray absorptiometry Markers of bone turnover (iPTH, osteocalcin, bone alkaline phosphatase, serum C-telopeptide), 25-hydroxy (OH) vitamin D(3) and nutritional markers (prealbumin, nPNA, BMI) were measured by standard techniques Results Of the 91 patients, 48 were female and 22 (24%) had Type 2 diabetes Mean age of the patients was 52 7, and patients had been on PD for about 44 months For the lumbar spine (LS) and femoral neck (FN), the mean T-scores were -1 19 +/- 1 53 and 1 24 +/- 1 01, respectively, and the mean Z-scores were -0 78 +/- 1 33 and -0 40 +/- 0 92, respectively Using the WHO-based criteria, osteopenia (-2 5 < T-score < -1 0) at the LS and FN was observed in 37 (41%) and 48 (53%) patients, respectively, and osteoporosis (T-score <= -2 5) at the LS and FN was observed in 15 (17%) and 6 (7%) patients, respectively LS T-score was positively correlated with BMI (r = 0 40, p < 0 001) and albumin (r = 0 29, p = 0 005), and FN T-score was positively correlated with albumin (r = 0 40, p < 0 001), prealbumin (r = 038, p < 0 001), age (r = -0 32, p = 0 002) and BMI (r = 0 29, p < 0 006) Markers of bone turnover were not associated with BMD In multiple linear regression models, independent predictors of FN T-score were age, BMI, albumin and prealbumin (r(2) = 0 259, F = 6 23, p < 0 001), whereas BMI was the only independent predictor of LS T-score (r(2) = 0 24, F = 6 63, p < 0 001) Conclusion Nutritional markers, not markers of bone turnover, are correlated predictors of BMD in CPD patients
- 出版日期2010-11
