Diagnostic value of exercise-induced changes in circulating high sensitive troponin T in stable chest pain patients

作者：Mouridsen Mette Rauhe^*; Nielsen Olav Wendelboe; Pedersen Ole Dyg; Carlsen Christian Malchau; Intzilakis Theodoros; Binici Zeynep; Sajadieh Ahmad

来源：Biomarkers, 2013, 18(8): 726-733.

DOI：10.3109/1354750X.2013.854835

• Cardiac troponin T
• coronary artery disease
• diagnostic tests
• exercise testing
• stable angina pectoris

Objective: We investigated the diagnostic value of exercise-induced increase in cardiac Troponin T (cTnT) in stable chest pain subjects.
Methods: CTnT was measured before and 20 h after an exercise test in 157 subjects suspected of coronary artery disease (CAD).
Results: CAD subjects (n = 41) had higher baseline cTnT levels compared to non-CAD subjects (n = 116), 6.39 ng/l and 3.00 ng/l, respectively, p<0.0001, and were more likely to increase in cTnT (70.7% versus 27.6%, p<0.0001). Net Reclassification Index for the combined variable was 19%, p = 0.02.
Conclusions: Exercise-induced increase in cTnT was found to be associated with CAD and cTnT measurements improved the diagnostic evaluation.

• 出版日期2013-12