A Convenient Synthesis of alpha-Substituted beta,gamma-Unsaturated Ketones and Esters via the Direct Addition of Substituted Allylic Zinc Reagents Prepared by Direct Insertion

Saemann Christoph; Knochel Paul<sup>*</sup>

doi:10.1055/s-0033-1338415

登录

免费注册

赞收藏引用

科研之友

微信

新浪微博

Facebook

分享链接

A Convenient Synthesis of alpha-Substituted beta,gamma-Unsaturated Ketones and Esters via the Direct Addition of Substituted Allylic Zinc Reagents Prepared by Direct Insertion

作者：Saemann Christoph; Knochel Paul^*

来源：Synthesis, 2013, 45(13): 1870-1876.

DOI：10.1055/s-0033-1338415

摘要

A practical and convenient procedure for the synthesis of alpha-substituted beta,gamma-unsaturated ketones and esters has been developed. Substituted allylic zinc reagents, prepared via direct metal insertion in substituted allylic halides, react readily with a broad range of acid chlorides and chloroformates furnishing the corresponding alpha-substituted beta,gamma-unsaturated ketones and esters in high yield and perfect regioselectivity.