科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background: Substituted amylose (SA) has been developed as excipient for direct compression matrices in the formulation of sustained release solid dosage forms. Method: The gel performance of SA for controlling water diffusion was studied by measuring water content in SA tablets prepared by direct compression. Results: The SA gel was not freely swelling and results indicate that water content in equilibrium state was dependent on tablet size but not on compression force. The presence of electrolyte and hydrophobic lubricant played an effective role in adjusting water diffusion in SA gel. In addition, a numerical model based on finite difference method was developed that exhibits a high goodness of fit to experimental result. The output of the model was not only the macroscopic water content value but also the water distribution within SA tablets.</.
- 出版日期2010-4
