Microwave-assisted solid acid-catalyzed one-pot synthesis of isobenzofuran-1(3H)-ones

作者：Landge Shainaz M; Berryman Martin; Toeroek Bela

来源：Tetrahedron Letters, 2008, 49(29-30): 4505-4508.

DOI：10.1016/j.tetlet.2008.05.068

• condensation
• isobenzofuran-1(3H)-one
• microwave irradiation
• montmorillonite K-10

A new, solid acid-catalyzed microwave-assisted environmentally benign synthesis of isobenzofuran-1(3H)-ones is described. Montmorillonite K-10 appeared to be an excellent catalyst for the condensation and successive lactonization reactions. Reaction of phthalaldehydic acid (2-arboxybenzaldehyde) with methylaryl and cyclic ketones was initiated by microwave irradiation and occurred in one step. The reactions were complete in 10-30 minutes providing excellent yields (90-98%).

• 出版日期2008-7-21