A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)(2) peptide delivery

作者:Lee Bo Reum; Oh Kyung Taek; Oh Young Taik; Baik Hye Jung; Park So Young; Youn Yu Seok; Lee Eun Seong*
来源:Chemical Communications, 2011, 47(13): 3852-3854.
DOI:10.1039/c0cc03590d

摘要

We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as 'GCS-g-DMA' hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.

  • 出版日期2011