Maintaining high rates of measles immunization in Africa

作者：Lessler J^*; Moss W J; Lowther S A; Cummings D A T

来源：Epidemiology and Infection, 2011, 139(7): 1039-1049.

DOI：10.1017/S0950268810002232

• Measles (rubeola)
• vaccination (immunization)

Supplementary immunization activities (SIAs) are important in achieving high levels of population immunity to measles virus. Using data from a 2006 survey of measles vaccination in Lusaka, Zambia, we developed a model to predict measles immunity following routine vaccination and SIAs, and absent natural infection. Projected population immunity was compared between the current programme and alternatives, including supplementing routine vaccination with a second dose, or SIAs at 1-, 2-, 3-, 4- and 5-year intervals. Current routine vaccination plus frequent SIAs could maintain high levels of population immunity in children aged <5 years, even if each frequent SIA has low coverage (e.g. >= 72% for bi-annual 60% coverage SIAs vs. >= 69% for quadrennial 95% coverage SIAs). A second dose at 12 months with current coverage could achieve 81% immunity. Circulating measles virus will only increase population immunity. Public health officials should consider frequent SIAs when resources for a two-dose strategy are unavailable.

• 出版日期2011-7