A convenient method to synthesize phosphinic peptides containing an aspartyl or glutamyl aminophosphinic acid. Use of the phenyl group as the carboxyl synthon.

作者：Georgiadis D; Matziari M; Vassiliou S; Dive V; Yiotakis A^*

来源：Tetrahedron, 1999, 55(51): 14635-14648.

DOI：10.1016/S0040-4020(99)00910-2

Many attempts to synthesize Asp Psi(PO2CH2)Ala phosphinic pseudodipeptides by Michael addition of aspartyl aminophosphinic acid to ethyl methacrylate have failed. The preparation of such phosphinic peptides was finally achieved starting from a protected Phe Psi(PO2CH2)Ala phosphinic building block. The key step is a mild oxidation of the phenyl group to carboxylic acid by use of the ruthenium trichloride-sodium metaperiodate system.

• 出版日期1999-12-17
• 单位中国地震局