Non-motor symptoms and the quality of life in multiple system atrophy with different subtypes

作者：Zhang, LingYu; Cao, Bei; Ou, Ruwei; Wei, Qian-Qian; Zhao, Bi; Yang, Jing; Wu, Ying; Shang, HuiFang^*

来源：Parkinsonism & Related Disorders, 2017, 35: 63-68.

DOI：10.1016/j.parkreldis.2016.12.007

• Multiple system atrophy
• Multiple system atrophy with predominately parkinsonism
• Multiple system atrophy with predominately cerebellar ataxia
• Non-motor symptoms
• Quality of life

Background: The differences in non-motor symptoms (NMS) and quality of life (QOL) between MSA patients with different subtypes remain unknown, so do the determinants of poor QOL in both subtypes. @@@ Methods: A total of 172 MSA patients were enrolled in the study. NMS of patients with MSA were assessed using the non-motor symptoms scale (NMSS) and Parkinson's Disease Questionnaire-39 item version (PDQ-39) was used to evaluate the QOL of patients with MSA. @@@ Results: The most prevalent NMS domain was urinary (913%) in both subtypes. The mood/apathy domain was more severe in MSA-P than MSA-C patients (P < 0.05). Drooling, constipation, and pain symptoms were more prevalent and severe in the MSA-P patients compared to the MSA-C patients (P < 0.05). We found that the MSA-C patients had a higher score of mobility than the MSA-P patients (P = 0.002); However, the MSA-P patients had a higher score of bodily discomfort than the MSA-C patients (P = 0.036). There were close correlations between NMS and PDQ-39 in both subtypes. Disease severity, cardiovascular symptoms, sleep/fatigue symptoms and gastrointestinal symptoms were determinants of poor QOL in MSA-P patients. While in MSA-C patients, longer disease duration, disease severity and mood/apathy symptoms were determinants of poor QOL. @@@ Conclusion: NMS are more severe and prevalent in MSA-P patients, especially for mood/apathy and gastrointestinal symptoms. There is a close relationship between NMS and QOL in both MSA subtypes. Disease severity, longer disease duration and severe NMS are determinants of poor QOL in MSA.

• 出版日期2017-2
• 单位四川大学