Nanotemplating of Biodegradable Polymer Membranes for Constant-Rate Drug Delivery

作者:Bernards Daniel A; Desai Tejal A*
来源:Advanced Materials, 2010, 22(21): 2358-2362.
DOI:10.1002/adma.200903439

摘要

A nanoporous biodegradable polymer (polycaprolactone) is fabricated utilizing a zinc oxide nanotemplate (see figure). Chemical characterization verifies removal of the template, and preliminary tests on the cytotoxicity demonstrate basic bio-compatibility. Diffusion of a model small molecule and a protein are shown to be first and zero order, respectively, indicating these nanoporous membranes may be useful for controlled release of protein-based therapeutics.

  • 出版日期2010-6-4