Association between areca-stimulated vimentin expression and the progression of head and neck cancers

作者：Tseng Yu Hsin; Chang Kuo Wei; Yang Cheng Chieh; Liu Chung Ji; Kao Shou Yen; Liu Tsung Yun; Lin Shu Chun^*

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2012, 34(2): 245-253.

DOI：10.1002/hed.21726

• areca nut chewing
• head and neck cancer
• invasion
• vimentin

Background Areca nut chewing is a common oral habit of Asians that is closely associated with the high incidence of head and neck carcinoma. The purpose of this study was to investigate the impacts of areca nut chewing on neoplastic process of head and neck carcinoma. %26lt;br%26gt;Methods. Head and neck carcinoma cells were treated with areca nut extract to perceive the phenotypic impacts. Tumor tissues were analyzed with immunohistochemistry (IHC) to understand the association between areca-associated molecular changes and clinical variables. %26lt;br%26gt;Results. Upon treatment with areca nut extract, carcinoma cells showed the increase of vimentin. The activation of extracellular signal-regulated kinase (ERK)/cyclooxygenase (COX)-2/prostaglandin (PGE)-2 cascade underlay the upregulation. These cells also exhibited the enhancement of migration and invasion. By knocking down COX-2 and vimentin expression, the increase of cell mobility was reversed. Tumor exhibiting extensive vimentin and/or COX-2 expression displayed a significantly worse disease-associated survival than contrast groups. %26lt;br%26gt;Conclusion. Areca-modulated vimentin expression enhanced the progression of head and neck carcinoma.

• 出版日期2012-2