delta ENaC: a novel divergent amiloride-inhibitable sodium channel

作者：Ji Hong Long^*; Zhao Run Zhen; Chen Zai Xing; Shetty Sreerama; Idell Steven; Matalon Sadis

来源：American Journal of Physiology - Lung Cellular and Molecular Physiology, 2012, 303(12): L1013-L1026.

DOI：10.1152/ajplung.00206.2012

• non-voltage-dependent sodium channels
• genetics
• pharmacology
• biophysics
• physiological regulation
• diseases

Ji HL, Zhao RZ, Chen ZX, Shetty S, Idell S, Matalon S. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol 303: L1013-L1026, 2012. First published September 14, 2012; doi: 10.1152/ajplung.00206.2012.-The fourth subunit of the epithelial sodium channel, termed delta subunit (delta ENaC), was cloned in human and monkey. Increasing evidence shows that this unique subunit and its splice variants exhibit biophysical and pharmacological properties that are divergent from those of alpha ENaC channels. The widespread distribution of epithelial sodium channels in both epithelial and nonepithelial tissues implies a range of physiological functions. The altered expression of SCNN1D is associated with numerous pathological conditions. Genetic studies link SCNN1D deficiency with rare genetic diseases with developmental and functional disorders in the brain, heart, and respiratory systems. Here, we review the progress of research on delta ENaC in genomics, biophysics, proteomics, physiology, pharmacology, and clinical medicine.

• 出版日期2012-12