Angiogenesis-related biomarkers (sFlt-1/PlGF) in placental mesenchymal dysplasia

作者：Herraiz Ignacio; Simon Elisa; Toldos Oscar; Rodriguez Yolanda; Gomez Arriaga Paula I; Galindo Alberto^*

来源：Journal of Maternal-Fetal and Neonatal Medicine, 2017, 30(8): 958-961.

DOI：10.1080/14767058.2016.1192600

• Angiogenic factors
• Beckwith-Wiedemann syndrome
• intrauterine growth restriction
• placental dysfunction
• placental growth factor
• soluble fms-like tyrosine kinase-1

Determination of the soluble fms-like tyrosine kinase-1 to placental growth factor ratio (sFlt-1/PlGF) in the maternal serum is expected to aid in the monitoring and decision-making process of women at risk for placental dysfunction. We report two cases of placental mesenchymal dysplasia (PMD) with sFlt-1/PlGF correlation. The first case is a dichorionic twin pregnancy with one fetus affected by PMD and Beckwith-Wiedemann syndrome in which a high value of sFlt-1/PlGF was found, coinciding with acute maternal and fetal wellbeing decline at 31 weeks. The second case corresponds to a singleton pregnancy diagnosed of PMD with normal sFlt-1/PlGF and favorable outcome.

• 出版日期2017-4