microRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma

作者：Strong Ashley M Poenitzsch; Setaluri Vijayasaradhi; Spiegelman Vladimir S^*

来源：Archives of Biochemistry and Biophysics, 2014, 563: 118-124.

DOI：10.1016/j.abb.2014.07.012

• microRNA
• miR-340
• Melanoma
• Tumor suppressor
• Proliferation
• Invasion
• RAS
• RAF
• MAPK

microRNA (miRNA)-dependent regulation of gene expression is increasingly linked to development and progression of melanoma. In this study we evaluated the functions of miR-340 in human melanoma cells. Here, we show that miR-340 inhibits the tumorigenic phenotype of melanoma cells. We also found that miR-340 regulates RAS-RAF-Mitogen Activated Protein Kinase (MAPK) signaling by modulating the expression of multiple components of this pathway. Given the importance of MAPK signaling in melanoma, these results provide further insight into the pathogenesis of melanoma.

• 出版日期2014-12-1