The copper(I)-catalyzed tandem reaction of o-alkynylphenyl isothiocyanates with isocyanides: a rapid synthesis of 5H-benzo[d] imidazo[5,1-b][1,3] thiazines

作者：Hao, Wenyan; Zeng, Jiangbo; Cai, Mingzhong^*

来源：Chemical communications, 2014, 50(79): 11686-11689.

DOI：10.1039/c4cc04057k

• MULTICOMPONENT REACTIONS
• ALPHA-ISOCYANOACETATES
• ADDITION-CYCLIZATION
• CATALYZED REACTION
• ORGANIC-SYNTHESIS
• DERIVATIVES
• DIVERSITY
• CYCLOADDITION
• NUCLEOPHILES
• ACETYLENES

An efficient route to 5H-benzo[d] imidazo[5,1-b][1,3] thiazines has been developed using the copper(I)-catalyzed tandem reaction of o-alkynylphenyl isothiocyanates with isocyanides in THF with Cs2CO3 as base. The present tandem process allows the assembly of a variety of 5H-benzo[d] imidazo[5,1-b][1,3] thiazines in good to excellent yields.

• 出版日期2014
• 单位江西师范大学