Association Between Tumor Necrosis Factor-alpha-308G/A Polymorphism and Obstructive Sleep Apnea: A Meta-Analysis

作者：Huang, Jian; Liao, Ning; Huang, Qiu-Pin; Xie, Zheng-Fu^*

来源：Genetic Testing and Molecular Biomarkers, 2012, 16(4): 246-251.

DOI：10.1089/gtmb.2011.0170

• ALPHA GENE POLYMORPHISM
• TNF-ALPHA
• PROMOTER POLYMORPHISM
• HYPOPNEA SYNDROME
• CYTOKINES
• HEALTH

Background and objective: The tumor necrosis factor (TNF)-alpha-308G/A polymorphism has been implicated in susceptibility to obstructive sleep apnea (OSA). However, results from previous studies are inconsistent. A systematic review and meta-analysis of the published studies was performed to investigate this association. Method: We searched PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Weipu databases for published studies evaluating the association between -308G/A polymorphism and OSA. Data were extracted using standardized forms and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Results: Four case-control studies involving a total of 419 cases and 460 controls were included in the meta-analysis. Combined data indicated that individuals carrying the -308A allele had a 65% increased risk of developing OSA when compared with the GG homozygotes (OR = 1.65, 95% CI = 1.02-2.68, p = 0.04). In adults, the risk was even higher, elevated by 100% (OR = 2.00, 95% CI = 1.26-3.18, p = 0.003). Conclusion: The TNF-alpha-308G/A polymorphism contributes to the risk of OSA, especially in adults.

• 出版日期2012-4
• 单位广西医科大学