科研之友
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摘要
The synthesis of the sesquiterpene endoperoxide natural product 10,12-peroxycalamenene has been achieved. Featured transformations include an intramolecular Heck reaction to build the fused bicyclic core and a cobalt-catalyzed peroxidation to install the peroxide functional group. The final step involved an S(N)1-type ring closure catalyzed by DDQ to construct the 1,2-dioxepane ring.
- 出版日期2015-8-21
