Mast cell adhesion induces cytoskeletal modifications and programmed cell death in oligodendrocytes

作者：Medic Nevenka; Lorenzon Paola; Vita Francesca; Trevisan Elisa; Marchioli Anna; Soranzo Maria Rosa; Fabbretti Elsa; Zabucchi Giuliano^*

来源：Journal of Neuroimmunology, 2010, 218(1-2): 57-66.

DOI：10.1016/j.jneuroim.2009.10.011

• Mast cell
• Oligodendrocyte
• Peptidyl-arginyl-deiminase
• Cytoskeleton

In this paper we show that rat peritoneal mast cells (RPMC) adhere to rat oligodendrocytes (ODC) in culture and switch on a bi-directional signal affecting both adhering cell and its target. Following heterotypic interaction, RPMC release granule content and ODC show morphological changes and enter the apoptotic programme. Altogether, these findings indicate that the interaction of MC with ODC could play a role in the mechanism of CNS damage induced by the inflammatory reaction.

• 出版日期2010-1-25