Antidyslipidemic activity of polyprenol from Coccinia grandis in high-fat diet-fed hamster model

作者：Singh Geetu; Gupta Prasoon; Rawat Preeti; Puri Anju; Bhatia Gitika; Maurya Rakesh^*

来源：Phytomedicine, 2007, 14(12): 792-798.

DOI：10.1016/j.phymed.2007.06.008

• Coccinia grandis
• polyprenols
• antidystipidemia
• hamster model

Ethanol extract of Coccinia grandis (L.) Voigt showed significant triglyceride (TG) and cholesterol-lowering effects in dyslipidemic hamster model. Ethanolic extract was fractionated into chloroform, n-butanol and water-soluble fractions and were evaluated. Activity was proved to be concentrated in chloroform-soluble fraction. Chloroform-soluble fraction containing active component was subjected to repeated column chromatography, furnished a polyprenol characterized as C-60-Polyprenol (1) isolated for the first time from this plant. It significantly decreased serum TG by 42%, total cholesterol (TC) 25% and glycerol (Gly) 12%, accompanied HDL-C/TC ratio 26% in high-fat diet (HFD)-fed dyslipidemic hamsters at the dose of 50 mg/kg body weight. Results are comparable to standard drug fenofibrate at the dose of 108 mg/kg. Based on these investigations, it was concluded that the compound polyprenol (1) isolated from leaves of C grandis possess marked antidyslipidemic activity.

• 出版日期2007-12