NICKEL - PROMOTED FAVORSKII TYPE REARRANGEMENT OF CYCLIC alpha-BROMOKETONES

作者：Tandon Vishnu K^*; Awasthi Anoop K; Singh Kunwar A; Maurya Hardesh K; Gautam Sanjay K

来源：Heterocycles, 2010, 80(1): 593-600.

DOI：10.3987/COM-08-S(S)4

• Favorskii Rearrangement
• NiCl2
• Cyclic alpha-Bromoketone
• Benzopyran
• Benzoxepine

Favorskii type rearrangement of cyclic a-bromo ketones 2 is promoted by NiCl2 in refluxing methanol, giving the rearranged carboxylic acid ester 3 in excellent yields. The reaction of 4-bromo-2,3,4,5-tetrahydronaphth [2,1-b]oxepin-5-one (5) and its regioisomer 8 with NiCl2 in MeOH resulted in Favorskii rearranged carboxylic acid esters 6 and 9 respectively.

• 出版日期2010-1-1