科研之友
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摘要
The chlorination of the carboxylic acid unit of alpha-aminoacids is an important reaction in organic synthesis, and the resulting compounds are usually seen as reactive intermediate species. Herein we report a straightforward procedure to obtain [MCl6](-) salts (M = Nb, 2a; Ta, 2b) of the L-proline-derivative (pyrrolidinium-2-carbonylchloride). These are stable up to 80 degrees C, in the solid state as well as in organic solvents. The X-ray structures determined for 2a, b include the first example of a crystallographically-characterized alpha-ammonium-acylchloride.
- 出版日期2014
