科研之友
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摘要
Mastic gum (MG) is a nature extracted product of the plant Pistacia lentiscus var. chia and has various effects such as antioxidant and anti-inflammatory effects. Thymic stromal lymphopoietin (TSLP) is increased in the asthmatic airway and induces dendritic cell-mediated activation of T(H)2 inflammatory responses. Viral stimuli, a major cause of asthma exacerbations, have been shown to induce overexpression of TSLP in asthmatic epithelium. However, the effect of MG on the production of TSLP has not been investigated. Here we have explored effects of MG on viral surrogate (dsRNA)-induced TSLP in human bronchial epithelial (NHBE) cells. NHBE were stimulated with dsRNA in the presence of IL-4 and IL-13. TSLP release was measured by ELISA. The effects of MG were analyzed. We demonstrated that mastic gum inhibited the production and mRNA expression of TSLP in normal human bronchial epithelial cells or in the asthmatic airway of mice. Mastic gum also inhibited the nuclear factor (NF)-kappa B luciferase activity induced by poly I:C, and it prevented dsRNA-induced loss of the NF-kappa B repressor protein I kappa B alpha. These results suggest that mastic gum may alleviate inflammatory and atopic diseases through the inhibition of TSLP.
