Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification

作者：Lee Sichul; Kim You Sun; Jeon Un Sil; Kim Yoon Keun; Schjoerring Jan K; An Gynheung^*

来源：Molecules and Cells, 2012, 33(3): 269-275.

DOI：10.1007/s10059-012-2231-3

• anemia
• bioavailability
• mouse
• rice

Because micronutrients in human diets ultimately come from plant sources, malnutrition of essential minerals is a significant public health concern. By increasing the expression of nicotianamine synthase (NAS), we fortified the level of bioavailable iron in rice seeds. Activation of iron deficiency-inducible OsNAS2 resulted in a rise in Fe content (3.0-fold) in mature seeds. Its ectopic expression also increased that content. Enhanced expression led to higher tolerance of Fe deficiency and better growth under elevated pH. Mice fed with OsNAS2-D1 seeds recovered more rapidly from anemia, indicating that bioavailable Fe contents were improved by this increase in OsNAS2 expression.

• 出版日期2012-3