A New Synthetic Route to Unsymmetrical 9-Arylxanthenes

作者：Das Sajal Kumar; Singh Ritesh; Panda Gautam^*

来源：European Journal of Organic Chemistry, 2009, 2009(28): 4757-4761.

DOI：10.1002/ejoc.200900676

• Fused-ring systems
• Oxygen heterocycles
• Arenes
• Synthetic methods

A facile and general three-step synthetic route towards unsymmetrical 9-arylxanthenes was developed. The reaction sequence involves nucleophilic substitution of commercially available 2-fluorobenzaldehydes with arenoxides, Grignard reaction of the resulting 2-arenoxybenzaldehydes with aryl-magnesium bromides, followed by FeCl(3)-catalyzed intramolecular diarylmethylation of the resulting carbinols. This strategy was extended to access symmetrical as well as unsymmetrical 9-arylthioxanthenes.

• 出版日期2009-10