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摘要
This paper proposed new competitive methods for fluorescence detection of the anti-cancer drug oxaliplatin. The methods were based on the competitive reaction of palmatine (PAL)/berberine (BER)/coptisine (COP) with oxaliplatin for the occupancy of cucurbit[7]uril (CB[7]) cavities. The results showed that the fluorescence intensity of PAL, BER, and COP regularly increased upon addition of CB[7] until a certain amount of oxaliplatin was added, at which stage the fluorescence intensity of the system quenched. Using the CB[7]-PAL, CB[7]-BER, and CB[7]-COP systems, linear ranges in the detection of oxaliplatin of 0.005-1.75, 0.010-1.50, and 0.020-1.05gmL(-1), with detection limits of 2, 3, and 7ngmL(-1), respectively, were obtained. These results suggest that cucurbit[7]uril is a promising drug carrier for delivering and monitoring targeted oxaliplatin, with improved anti-tumour efficacy and reduced toxicity in normal tissues.
- 出版日期2017
- 单位山西师范大学
