A multi-agent model describing self-renewal of differentiation effects on the blood cell population

作者：Bessonov Nikolai; Demin Ivan; Pujo Menjouet Laurent^*; Volpert Vitaly

来源：Mathematical and Computer Modelling, 2009, 49(11-12): 2116-2127.

DOI：10.1016/j.mcm.2008.07.023

• Hematopoiesis
• Anemia
• Multi-agent model
• Self-renewal
• Cell communication

In this work, a new multi-agent model is used to describe blood cell population dynamics. More particularly, we focus our simulations here on differentiation and self-renewal process based on cell communication. We consider the different cases where progenitor cells are able to self-renew or not in the bone marrow. As a consequence of this study, we give some possible explanations of the mechanism for recovery of the system under important blood loss or blood diseases such as anemia.

• 出版日期2009-6